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NMS-P118

NMS-P118

Item no.	V2692-250mg
Manufacturer	InvivoChem LLC
CASRN	1262417-51-5
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2692CAS #:1262417-51-5Purity >=98% Description: NMS-P118 is a novel potent, orally available, and highly selective PARP-1 (protein poly(ADP-ribose) polymerase-1) inhibitor with 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 uM vs 1.39 uM, respectively). It has been investigated for cancer treatment. NMS-P118 has excellent ADME and pharmacokinetic properties, and is proved to be metabolically stable, it modestly inhibits two cytochrome P450 family members (CYP-2B6 IC50, 8.15 uM; CYP-2D6 IC50, 9.51 uM) out of eight isoforms tested. NMS-P118 has low in vivo clearance, and complete oral bioavailability. Description: References: J Med Chem. 2015 Sep 10; 58(17):6875-98. References:
Molecular Weight (MW)	395.42
Formula	C20H24F3N3O2
CAS No.	1262417-51-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 24 mg/mL (60.7 mM)
	Water: < 1 mg/mL
	Ethanol: 5 mg/mL (12.6 mM)
Solubility (In vivo)	O=C(C1=CC(F)=CC(CN2C3CCN(C4CCC(F)(F)CC4)CC3)=C1C2=O)N
Synonyms	NMS-P118; NMS-P 118; NMS P118.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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