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Enasidenib (AG-221)

Enasidenib (AG-221)

Item no.	V2851-100mg
Manufacturer	InvivoChem LLC
CASRN	1446502-11-9
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2851CAS #:1446502-11-9 Purity >=98% Description: Enasidenib (formerly known as AG-221 and CC-90007) is an oral, first-in-class, potent and selective inhibitor of IDH2 (Isocitrate dehydrogenase 2) with potential anticancer activity. Enasidenib inhibits mutant IDH2-mediated 2-HG production in vivo and reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Clinical trials combining IDH2 inhibitors with other targeted AML therapies are warranted in order to increase therapeutic efficacy. References: Blood 2014 124:437; http://cancerres.aacrjournals.org/content/74/19_Supplement/3116 Related CAS#:1650550-25-6 (mesylate)
Molecular Weight (MW)	473.38
Formula	C19H17F6N7O
CAS No.	1446502-11-9 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 94 mg/mL (198.57 mM)
	Water: < 1 mg/mL
	Ethanol: 94 mg/mL (198.57 mM)
SMILES Code	CC(O)(C)CNC1=NC(C2=NC(C(F)(F)F)=CC=C2)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N1
Synonyms	AG-221; AG 221; AG221; Enasidenib; CC-90007; CC 90007; CC90007

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Amount: 100 mg

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Delivery expected until 9/4/2025

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