ML355

Item no.	V3027-10mg
Manufacturer	InvivoChem LLC
CASRN	1532593-30-8
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3027CAS #:1532593-30-8Purity >=98% Description: ML355 is the first selective, orally bioavailable 12-LOX inhibitor which displays high potency (IC50 of 0.34 uM) against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. ML355 has favorable ADME/Pharmacokinetic properties, it inhibits PAR-4 induced aggregation and calcium mobilization in human platelets, and reduces 12-HETE in mouse/human beta cells suggesting its potential utility in animal models for antiplatelet therapy and diabetes. ML355 treatment impaired thrombus growth and vessel occlusion in FeCl3-induced mesenteric and laser-induced cremaster arteriole thrombosis models in mice. Description: References: Arterioscler Thromb Vasc Biol. 2017 Oct; 37(10):1828-1839. References:
Molecular Weight (MW)	441.52
Formula	C21H19N3O4S2
CAS No.	1532593-30-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 40 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	15mg/kg in DMSO:Solutol:PEG400:water; 5:10:20:65
Synonyms	ML-355; ML 355; ML355;

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Amount: 10 mg

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