ML355

Item no.	V3027-50mg
Manufacturer	InvivoChem LLC
CASRN	1532593-30-8
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3027CAS #:1532593-30-8Purity >=98% Description: ML355 is the first selective, orally bioavailable 12-LOX inhibitor which displays high potency (IC50 of 0.34 uM) against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. ML355 has favorable ADME/Pharmacokinetic properties, it inhibits PAR-4 induced aggregation and calcium mobilization in human platelets, and reduces 12-HETE in mouse/human beta cells suggesting its potential utility in animal models for antiplatelet therapy and diabetes. ML355 treatment impaired thrombus growth and vessel occlusion in FeCl3-induced mesenteric and laser-induced cremaster arteriole thrombosis models in mice. Description: References: Arterioscler Thromb Vasc Biol. 2017 Oct; 37(10):1828-1839. References:
Molecular Weight (MW)	441.52
Formula	C21H19N3O4S2
CAS No.	1532593-30-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 40 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	15mg/kg in DMSO:Solutol:PEG400:water; 5:10:20:65
Synonyms	ML-355; ML 355; ML355;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 29 days

Compare

Add to wishlist

Get an offer