« Back
Home /
Padnarsertib (KPT-9274)

Padnarsertib (KPT-9274)

Item no.	V3144-10mg
Manufacturer	InvivoChem LLC
CASRN	1643913-93-2
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3144CAS #:1643913-93-2Purity >=98% Description: This product has been discontinued. KPT-9274 (PAK4-IN-1) is a potent, selective, orally bioavailable small molecule, non-competitive dual inhibitor of PAK4/NAMPT inhibitor. KPT-9274 disrupts the PAK4/NAMPT signaling pathway, which may lead to the reduction of G2-M transit and induction of apoptosis as well as decrease in cell invasion and migration in several human RCC cell lines. Inhibition of the PAK4 signaling pathway by KPT-9274 attenuates nuclear beta-catenin as well as the Wnt/beta-catenin targets cyclin D1 and c-Myc. KPT-9274 demonstrated the expected on-target effects in a mouse model and is under a phase I clinical trial for solid tumors and lymphomas. Description: References: Mol Cancer Ther. 2016 Sep; 15(9):2119-29. References:
Molecular Weight (MW)	610.63
Formula	C35H29F3N4O3
CAS No.	1643913-93-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (163.8 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (163.8 mM)
Chemical Name	(1Z, 2E)-3-(6-aminopyridin-2-yl)-N-((5-(4-(4, 4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl) benzofuran-2-yl)methyl)acrylimidic acid
Synonyms	KPT9274; KPT-9274; KPT 9274; PAK4-IN-1; PAK4-IN 1; PAK4-IN1
SMILES Code	OC(/C=C/C1=NC(N)=CC=C1)=N\CC2=CC3=CC(C4=CC=C(C(N5CCC(F)(F)CC5)=O)C=C4)=CC(C6=CC=C (F)C=C6)=C3O2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer