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Velpatasvir

Velpatasvir

Item no.	V3158-500mg
Manufacturer	InvivoChem LLC
CASRN	1377049-84-7
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3158CAS #:1377049-84-7 Purity >=98% Description: Velpatasvir (formerly known as GS-5816 or VEL) is a potent, selective, second-generation inhibitor of Hepatitis C virus NS5A. It inhibits hepatitis C viral replication through acting on the crucial 'membranous web' that facilitates RNA replication. Velpatasvir is a pan-genotypic inhibitor of HCV nonstructural protein 5A (NS5A) with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir has demonstrated a high barrier to resistance in HCV replicon assays and a pangenotypic antiviral activity in patients with genotypes 1-4 HCV infection. It is being tested in combination with other pangenotypic direct-acting antivirals to obtain a well-tolerated, highly effective treatment option for all HCV genotypes. Description: References: Drug Des Devel Ther. 2017 Feb 23; 11:497-502; Antimicrob Agents Chemother. 2016 Aug 22; 60(9):5368-78. References:
Molecular Weight (MW)	883.00
Formula	C49H54N8O8
CAS No.	1377049-84-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: > 100 mg/mL
	Ethanol: > 100 mg/mL
Chemical Name	(33R, 34S, 35S, 91R, 92R, 5S)-5-(tert-butyl)-N-((1R, 2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl) carbamoyl)cyclopropyl)-34-ethyl-14, 14-difluoro-17-methoxy-4, 7-dioxo-2, 8-dioxa-6-aza-1(2, 3)-quinoxalina-3(3, 1)-pyrrolidina-9(1, 2)-cyclopropanacyclotetradecaphane-35-carboxamide
Synonyms	VEL; GS-5816; GS5816; GS 5816
SMILES Code	O=C(N([CH]1C)[CH](CC1)C2=NC3=C(C(C=C(OCC4=CC(C5=CN=C([CH](C[CH](COC)C6)N6C ([CH](C7=CC=CC=C7)NC(OC)=O)=O)N5)=CC=C84)C8=C9)=C9C=C3)N2)[CH](C(C)C)NC(OC)=O

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Amount: 500 mg

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