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BCX 1470 methanesulfonate

BCX 1470 methanesulfonate

Item no.	V31593-5mg
Manufacturer	InvivoChem LLC
CASRN	217099-44-0
Amount	5 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V31593CAS #:217099-44-0Purity >=98% Description:BCX 1470 methanesulfonate is a novel, potent and selective Serine protease inhibitorthat inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s(IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that oftrypsin. . CX 1470 blocks the esterolytic and hemolytic activities ofthe complement enzymes Cls and factor D in vitro, also blockeddevelopment of RPA-induced edema in the rat. BCX 1470 may be useful asan anti-inflammatory agent in diseases where complement activation isknown to be detrimental. References: The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468 Related CAS#: 217099-43-9 (free base) Description:BCX 1470 methanesulfonate is a novel, potent and selective Serine protease inhibitorthat inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s(IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that oftrypsin. . CX 1470 blocks the esterolytic and hemolytic activities ofthe complement enzymes Cls and factor D in vitro, also blockeddevelopment of RPA-induced edema in the rat. BCX 1470 may be useful asan anti-inflammatory agent in diseases where complement activation isknown to be detrimental. References: The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468 Related CAS#: 217099-43-9 (free base)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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