« Back
Home /
PF-06260933

PF-06260933

Item no.	V3214-250mg
Manufacturer	InvivoChem LLC
CASRN	1811510-56-1
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3214CAS #:1811510-56-1 Purity >=98% Description: PF-06260933 is a highly selective small-molecule inhibitor of MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) with IC50 values of 3.7 and 160 nM for cell-freel assay (kinase) and cell assay, respectively. It also inhibits MINK and TNIK with IC50 values of 8 and 13 nM, respectively. PF-06260933 has been reported to improve fasting hyperglycemia in mice. Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, PF-6260933. Description: References: ACS Med Chem Lett. 2015 Oct 6; 6(11):1128-33; Nat Commun. 2015 Dec 21; 6:8995. References: Related CAS#:2118243-34-6 (HCl); 1883548-86-4 (2HCl)
Molecular Weight (MW)	296.08
Formula	C16H13ClN4
CAS No.	1811510-56-1 (free base); 2118243-34-6 (HCl); 1883548-86-4 (2HCl)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 30 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	5-(4-Chlorophenyl)-[3, 3']bipyridinyl-6, 6'-diamine
Synonyms	PF-06260933; PF 06260933; PF06260933
SMILES Code	NC1=C(C2=CC=C(Cl)C=C2)C=C(C(C=N3)=CC=C3N)C=N1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 15 days

Compare

Add to wishlist

Get an offer