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PF-06260933

PF-06260933

Item no.	V3214-500mg
Manufacturer	InvivoChem LLC
CASRN	1811510-56-1
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3214CAS #:1811510-56-1 Purity >=98% Description: PF-06260933 is a highly selective small-molecule inhibitor of MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) with IC50 values of 3.7 and 160 nM for cell-freel assay (kinase) and cell assay, respectively. It also inhibits MINK and TNIK with IC50 values of 8 and 13 nM, respectively. PF-06260933 has been reported to improve fasting hyperglycemia in mice. Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, PF-6260933. Description: References: ACS Med Chem Lett. 2015 Oct 6; 6(11):1128-33; Nat Commun. 2015 Dec 21; 6:8995. References: Related CAS#:2118243-34-6 (HCl); 1883548-86-4 (2HCl)
Molecular Weight (MW)	296.08
Formula	C16H13ClN4
CAS No.	1811510-56-1 (free base); 2118243-34-6 (HCl); 1883548-86-4 (2HCl)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 30 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	5-(4-Chlorophenyl)-[3, 3']bipyridinyl-6, 6'-diamine
Synonyms	PF-06260933; PF 06260933; PF06260933
SMILES Code	NC1=C(C2=CC=C(Cl)C=C2)C=C(C(C=N3)=CC=C3N)C=N1

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Amount: 500 mg

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