Enfuvirtide

Description: Enfuvirtide, a peptide-based anti-HIV-1 fusion inhibitor, is an approved antiviral medication that prevents human immunodeficiency virus (HIV) from infecting healthy cells in the body. It has poor oral systemic availability and is given subcu-taneously. Enfuvirtide is used together with other medications to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Enfuvirtide is a linear 36-amino acid synthetic peptide with the N-terminus acetylated and the C-terminus is a carboxamide. It is composed of naturally occurring L-amino acid residues. Enfuvirtide is a white to off-white amorphous solid.

References:

1. FigueiraTN, et al. Quantitative analysis of molecular partition towards lipidmembranes using surface plasmon resonance. Sci Rep. 2017 Mar 30; 7:45647.

2. CaoP, et al. The improved efficacy of Sifuvirtide compared withEnfuvirtide might be related to its selectivity for the rigidbiomembrane, as determined through surface plasmon resonance. PLoS One.2017 Feb 16; 12(2):e0171567.

3. Wang X, et al. IFN-lambda Inhibits Drug-Resistant HIV Infection of Macrophages. Front Immunol. 2017 Mar 6; 8:210.