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Ivacaftor hydrate (VX-770)

Ivacaftor hydrate (VX-770)

Item no.	V3901-25mg
Manufacturer	InvivoChem LLC
CASRN	1134822-07-3
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3901CAS #:1134822-07-3 Purity >=98% Description: Ivacaftor (also known as VX-770; trade name: KALYDECO and Symdeko) is a potent and orally bioactive potentiator of CFTR (cystic fibrosis transmembrane conductance regulator) targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively. Ivacaftor is a drug used for the treatment of cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis. References: Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18825-30. Related CAS#: 1134822-09-5 (Ivacaftor benzenesulfonate); 873054-44-5 (free)
Molecular Weight (MW)	410.51
Formula	C??H??N?O?
CAS No.	1134822-07-3 (Ivacaftor hydrate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
SMILES	CC(C)(C1=C(C=C(C(C(C)(C)C)=C1)O)NC(C2=CNC3=C(C2=O)C=CC=C3)=O)C.O
Synonyms	VX770 hydrate; VX 770 hydrate; VX-770; Ivacaftor hydrate; Trade name: KALYDECO.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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