Comparison

SHA 68

Item no. V40180-10mg
Manufacturer InvivoChem LLC
CASRN 847553-89-3
Amount 10 mg
Quantity options 100 mg 25 mg 50 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V40180CAS #:847553-89-3Purity >=98%

Description: SHA 68 is a novel, highly potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.

References:

1. OkamuraN, et al. Synthesis and pharmacological in vitro and in vivo profile of3-oxo-1, 1-diphenyl-tetrahydro-oxazolo3, 4-apyrazine-7-carboxylic acid4-fluoro-benzylamide (SHA 68), a selective antagonist of theneuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun; 325(3):893-901.

2. EnshoT, et al. Neuropeptide S increases motor activity and thermogenesis inthe rat through sympathetic activation.Neuropeptides. 2017 Oct; 65:21-27.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
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