SHA 68

Item no.	V40180-25mg
Manufacturer	InvivoChem LLC
CASRN	847553-89-3
Amount	25 mg
Quantity options	100 mg 10 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V40180CAS #:847553-89-3Purity >=98% Description: SHA 68 is a novel, highly potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia. References: 1. OkamuraN, et al. Synthesis and pharmacological in vitro and in vivo profile of3-oxo-1, 1-diphenyl-tetrahydro-oxazolo3, 4-apyrazine-7-carboxylic acid4-fluoro-benzylamide (SHA 68), a selective antagonist of theneuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun; 325(3):893-901. 2. EnshoT, et al. Neuropeptide S increases motor activity and thermogenesis inthe rat through sympathetic activation.Neuropeptides. 2017 Oct; 65:21-27.

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Amount: 25 mg

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