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Description: TAS-301 is a novel, potent and selective inhibitor of smooth muscle cell migration and proliferation and inhibits intimal thickening after balloon injury to rat carotid arteries. TAS-103 inhibits smooth muscle cell migration and proliferation. It also inhibits intimal thickening after balloon injury to rat carotid arteries. TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. TAS-103 inhibits calcium-dependent signal transduction and cytoskeletal reorganization.
References: J Pharmacol Exp Ther. 1998 Jun; 285(3):1280-6.; Jpn J Pharmacol. 2000 Nov; 84(3):252-8.
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