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Description: Relebactam (also known as MK-7655) is a diazabicyclooctane that acts as a potent and selective beta-lactamase inhibitor. It has activity against a wide spectrum of beta-lactamases, including class A (extended-spectrum beta-lactamases ESBLs and KPC) and class C (AmpC) enzymes. Relebactam reduced imipenem MICs for Enterobacteriaceae with KPC carbapenemases from 16-64 mg/L to 0.12-1 mg/L. MK-7655 potentiated imipenem against Enterobacteriaceae with KPC carbapenemases or combinations of beta-lactamase and impermeability, but not those with metallo-carbapenemases. It augmented the activity of imipenem against P. aeruginosa in general and OprD mutants in particular.
References: Antimicrob Agents Chemother. 2015 Aug; 59(8):5029-31.; Int J Antimicrob Agents. 2015 Nov; 46(5):483-93.
Related CAS #: 1174020-13-3 (hydrate) 1174018-99-5 (free acid) 1502858-91-4 (sodium)
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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