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jnj-54175446

jnj-54175446

Item no.	V4505-10mg
Manufacturer	InvivoChem LLC
CASRN	1627902-21-9
Amount	10 mg
Quantity options	100 mg 1 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4505CAS #:1627902-21-9Purity >=98% Description: JNJ-54175446 is a novel, potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. JNJ-5417544 has suitable physicochemical properties, metabolic stability and an excellent pharmacokinetic profile, good partitioning into the CNS and show robust in vivo target engagement after oral dosing. JNJ-54175446 has been advanced as a candidate to clinical development. References: J Med Chem. 2017 Jun 8; 60(11):4559-4572
	Name: JNJ-54175446 CAS#: 1627902-21-9 Chemical Formula: C18H13ClF4N6O Exact Mass: 440.0775 Molecular Weight: 440.7866 Elemental Analysis: C, 49.05; H, 2.97; Cl, 8.04; F, 17.24; N, 19.07; O, 3.63
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: JNJ-54175446; JNJ 54175446; JNJ54175446 IUPAC/Chemical Name: (R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-1, 4, 6, 7-tetrahydro-5H-[1, 2, 3]triazolo[4, 5-c]pyridin-5-yl)methanone InChi Key: CWFVVQFVGMFTBD-SECBINFHSA-N InChi Code: InChI=1S/C18H13ClF4N6O/c1-9-15-13(29(27-26-15)17-24-7-10(20)8-25-17)5-6-28(9)16(30)11-3-2-4-12(14(11)19)18(21, 22)23/h2-4, 7-9H, 5-6H2, 1H3/t9-/m1/s1 SMILES Code: ClC1=C(C(F)(F)F)C=CC=C1C(N(CC2)[CH](C)C(N=N3)=C2N3C4=NC=C(C=N4)F)=O

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Amount: 10 mg

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Delivery expected until 9/4/2025

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