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jnj-54175446

jnj-54175446

Item no.	V4505-250mg
Manufacturer	InvivoChem LLC
CASRN	1627902-21-9
Amount	250 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4505CAS #:1627902-21-9Purity >=98% Description: JNJ-54175446 is a novel, potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. JNJ-5417544 has suitable physicochemical properties, metabolic stability and an excellent pharmacokinetic profile, good partitioning into the CNS and show robust in vivo target engagement after oral dosing. JNJ-54175446 has been advanced as a candidate to clinical development. References: J Med Chem. 2017 Jun 8; 60(11):4559-4572
	Name: JNJ-54175446 CAS#: 1627902-21-9 Chemical Formula: C18H13ClF4N6O Exact Mass: 440.0775 Molecular Weight: 440.7866 Elemental Analysis: C, 49.05; H, 2.97; Cl, 8.04; F, 17.24; N, 19.07; O, 3.63
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: JNJ-54175446; JNJ 54175446; JNJ54175446 IUPAC/Chemical Name: (R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-1, 4, 6, 7-tetrahydro-5H-[1, 2, 3]triazolo[4, 5-c]pyridin-5-yl)methanone InChi Key: CWFVVQFVGMFTBD-SECBINFHSA-N InChi Code: InChI=1S/C18H13ClF4N6O/c1-9-15-13(29(27-26-15)17-24-7-10(20)8-25-17)5-6-28(9)16(30)11-3-2-4-12(14(11)19)18(21, 22)23/h2-4, 7-9H, 5-6H2, 1H3/t9-/m1/s1 SMILES Code: ClC1=C(C(F)(F)F)C=CC=C1C(N(CC2)[CH](C)C(N=N3)=C2N3C4=NC=C(C=N4)F)=O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 250 mg

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Delivery expected until 9/4/2025

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