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Simurosertib

Simurosertib

Item no.	V4595-100mg
Manufacturer	InvivoChem LLC
CASRN	1330782-76-7
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4595CAS #:1330782-76-7Purity >=98% Description: Simurosertib (formerly known as TAK-931) is a novel, selective and orally bioavailable cycle 7 (CDC7, cell division cycle 7-related protein) kinase inhibitor, with an IC50< 0.3 nM. TAK-931 has potential antineoplastic activity by binding to and inhibiting CDC7 which prevents the initiation of DNA replication during mitosis, which causes cell cycle arrest and induces apoptosis. This inhibits cell growth in CDC7-overexpressing tumor cells. CDC7, a serine/threonine kinase and cell division cycle protein, is overexpressed in a variety of cancers and plays a key role in the activation of DNA replication and the regulation of cell cycle progression References: European Journal of Cancer , 2016 , 69 (1) :S34. Related CAS: 1330782-76-7; 1330782-69-8 (R-Simurosertib)
	Name: Simurosertib / TAK-931 CAS#: 1330782-76-7 Chemical Formula: C17H19N5OS Exact Mass: 341.131 Molecular Weight: 341.433 Elemental Analysis: C, 59.80; H, 5.61; N, 20.51; O, 4.69; S, 9.39
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: TAK-931; TAK 931; TAK931; Simurosertib IUPAC/Chemical Name: Thieno(3, 2-d)pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo(2.2.2)oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)- InChi Key: XGVXKJKTISMIOW-ZDUSSCGKSA-N InChi Code: InChI=1S/C17H19N5OS/c1-9-11(8-18-21-9)14-7-12-15(24-14)17(23)20-16(19-12)13-6-10-2-4-22(13)5-3-10/h7-8, 10, 13H, 2-6H2, 1H3, (H, 18, 21)(H, 19, 20, 23)/t13-/m0/s1 SMILES Code: O=C1C2=C(C=C(C3=CNN=C3C)S2)N=C([CH]4N(CC5)CCC5C4)N1

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Amount: 100 mg

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Delivery expected until 11/6/2025

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