AM404

Item no.	HY-101388-100mg
Manufacturer	MedChem Express
CASRN	183718-77-6
Amount	100 mg (126.4 mM x 2 mL in Ethanol)
Quantity options	100 mg (126.4 mM x 2 mL in Ethanol) 10 mg (126.4 mM x 200 uL in Ethanol) 1 ea 5 mg (126.4 mM x 100 uL in Ethanol)
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.0
Citations	[1] A Giuffrida, et al. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. J Pharmacol Exp Ther. 2001 Jul;298(1):7-14.\|[2]Kent-Olov Jonsson, et al. AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch Toxicol. 2003 Apr;77(4):201-7.\|[3]Marco Bortolato, et al. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 Dec;31(12):2652-9.
Smiles	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NC1=CC=C(O)C=C1)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Cannabinoid Receptor
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Molecular Weight	395.58
Product Description	AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range[1]. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Neuroprotective Effect[2].
Manufacturer - Research Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	No Development Reported

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HY-101388-100mg-safety-datasheet.pdf