SAK3

Item no.	HY-120597-50mg
Manufacturer	MedChem Express
CASRN	1256269-87-0
Amount	50 mg
Quantity options	10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.80
Citations	[1]Yasushi Yabuki, et al. Pharmacological properties of SAK3, a novel T-type voltage-gated Ca<sup>2+</sup> channel enhancer. Neuropharmacology. 2017 May 1;117:1-13.\|[2]Jing Xu, et al.T-Type Ca<sup>2+</sup> Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model. Int J Mol Sci. 2021 Jun 8;22(12):6185.
Smiles	O=C(OCC)C1=C(C2(CC1=O)N3C=CC=C(C3=NC2=O)C)N4CCCCC4
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Calcium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	369.41
Product Description	SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 2 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	T-type calcium channel
Clinical information	No Development Reported

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