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Hydroxy Bosentan-d4

Hydroxy Bosentan-d4

Item no.	HY-121385S1-1mg
Manufacturer	MedChem Express
CASRN	1065472-91-4
Amount	1 mg
Quantity options	1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.\|[2]Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8.
Smiles	COC1=CC=CC=C1OC2=C(OC([2H])([2H])C([2H])([2H])O)N=C(C3=NC=CC=N3)N=C2NS(C4=CC=C(C(C)(C)CO)C=C4)(=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Ro 48-5033-d4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Endogenous Metabolite; Isotope-Labeled Compounds
Shipping Temperature	Room temperature
Molecular Weight	571.64
Product Description	Hydroxy Bosentan-d4 is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease; Others
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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