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BS-181 (hydrochloride)

BS-181 (hydrochloride)

Item no.	HY-13266A-25mg
Manufacturer	MedChem Express
CASRN	1397219-81-6
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.93
Citations	[1]Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69(15):6208-15.\|[2]Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9. Int J Biol Macromol. 2024 Dec 27:139117.\|Universidade de Lisboa. 2021 Dec 21.\|Biochem Biophys Res Commun. 2019 Jun 11;513(4):967-973.\|Cell Rep. 2017 Dec 5;21(10):2796-2812.\|Theranostics. 2017 Apr 20;7(7):1914-1927.
Smiles	CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C.[H]Cl
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CDK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	416.99
Product Description	BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 50 mg/mL\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Isoform	CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Clinical information	No Development Reported

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HY-13266A-25mg-safety-datasheet.pdf