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Selnoflast

Selnoflast

Item no.	HY-132831-50mg
Manufacturer	MedChem Express
CASRN	2260969-36-4
Amount	50 mg
Quantity options	100 mg 10 mM x 1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.46
Formula	C20H29N3O3S
Citations	[1]Vande Walle L, et al. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nat Rev Drug Discov. 2023 Nov 29. [2]Klughammer B, et al. A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis. Clin Transl Med. 2023 Nov;13(11):e1471. [3]McManus RM, et al. NLRP3 inflammasome signalling in Alzheimer's disease[J]. Neuropharmacology. 2024 Jul 1;252:109941. [4]Teske KA, et al. Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays[J]. Cell Chem Biol. 2024 Feb 15;31(2):349-360.e6. [5]Zhang L, et al. Role of NLRP3 inflammasome in central nervous system diseases[J]. Cell Biosci. 2024 Jun 7;14(1):75.
Smiles	O=C(NS(=O)(C1CCN(CC1)CC)=O)NC2=C(CCC3)C3=CC4=C2CCC4
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Somalix, RO-7486967, IZD334
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Interleukin Related; NOD-like Receptor (NLR)
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	391.53
Product Description	Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2][3][4][5]
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	1M NaOH : 3.33 mg/mL (adjust pH to 12 with 1M NaOH)\|DMSO : 5 mg/mL (ultrasonic; adjust pH to 8 with 1M NaOH)
Manufacturer - Pathway	Immunology/Inflammation
Isoform	NLRP3
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-132831-50mg-safety-datasheet.pdf