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CCG-50014

CCG-50014

Item no.	HY-13509-100mg
Manufacturer	MedChem Express
CASRN	883050-24-6
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.62
Citations	[1]Blazer LL, et al. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50(15):3181-92.\|[2]Yoon SY, et al. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120(3):671-7.
Smiles	O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	RGS Protein
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	316.35
Product Description	CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 62.5 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein
Isoform	RGS16; RGS19; RGS4; RGS8
Clinical information	No Development Reported

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HY-13509-100mg-safety-datasheet.pdf