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2'-F-Bz-dC Phosphoramidite

2'-F-Bz-dC Phosphoramidite

Item no.	HY-138577-50mg
Manufacturer	MedChem Express
CASRN	161442-19-9
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 1 ea 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.88
Citations	[1]Reif B, et, al. Structural Comparison of Oligoribonucleotides and Their 2′-Deoxy-2′-fluoro Analogs by heteronuclear NMR spectroscopy. Helvetica Chimica Acta. 1997 Jou; 80(6): 1952-1971.\|[2]Zhang Hongyan, et al. Combined drug for treating hepatitis B and its application in preparing drugs for preventing and/or treating HBV (hepatitis B virus)-induced symptom or diseases. China, CN112007040 A. 2020-12-01. \|[3]Monia Brett P, et al. Antisense oligonucleotides for modulation of telomerase catalytic subunit gene expression and treatment of cancer. World Intellectual Property Organization, WO2001088198 A1. 2001-11-22.
Smiles	COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N4C=CC(NC(C5=CC=CC=C5)=O)=NC4=O)O3)C6=CC=CC=C6)C=C1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Oligonucleotides
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	851.90
Product Description	2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-138577-50mg-safety-datasheet.pdf