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Ro 31-8220

Ro 31-8220

Item no.	HY-13866A-1ea
Manufacturer	MedChem Express
CASRN	125314-64-9
Amount	1 ea
Quantity options	100 mg 10 mg 1 ea 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 ( Pt 2):335-7.\|[2]Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.\|[3]Tian F, et al. Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death. Neurotoxicology. 2007 Jul;28(4):843-9. Epub 2007 Apr 20.\|[4]Hambleton M, et al. Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation. 2006 Aug 8;114(6):574-82.\|[5]Beltman J, et al. The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. J Biol Chem. 1996 Oct 25;271(43):27018-24. Aging Cell. 2020 Oct;19(10):e13217. Aging Cell. 2022 Mar;21(3):e13573. Biomolecules. 2022 Mar 10;12(3):426. FASEB J. 2019 Feb;33(2):2435-2450. J Clin Invest. 2022 Feb 15;132(4):e150101. Mol Med Rep. 2017 Nov;16(5):5924-5930. Nat Commun. 2018 Sep 11;9(1):3688. Neurogastroenterol Motil. 2020 Oct;32(10):1514-1528. bioRxiv. 2024 Jul 25. EMBO Mol Med. 2023 Jan 11;15(1):e16373. Front Immunol. 2021 Feb 2:11:625542. Harvard Medical School LINCS LIBRARY Life Metab. 2025 Jan 29;4(2):loaf002.
Smiles	NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Bisindolylmaleimide IX
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	JNK; PKC
Manufacturer - HS Code	H302-H315-H319-H335
Shipping Temperature	Room temperature
Molecular Weight	457.55
Product Description	Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5].
Manufacturer - Research Area	Neurological Disease; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Epigenetics; MAPK/ERK Pathway; TGF-beta/Smad
Clinical information	No Development Reported
Isoform	PKC; PKCα; PKCβ; PKCγ; PKCε
UNSPSC Code	12352005
Precautionary	P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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