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Atirmociclib

Atirmociclib

Item no.	HY-139450-100mg
Manufacturer	MedChem Express
CASRN	2380321-51-5
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.87
Formula	C22H27ClFN5O3
Citations	[1]Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.
Smiles	CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](COCC4)O)=NC=C3Cl)=CC(F)=C2N=C1C(C)(O)C)C
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	PF-07220060, CDK4/6-IN-6
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CDK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	463.93
Product Description	Atirmociclib (PF-07220060; example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Isoform	CDK4; CDK6
Clinical information	Phase 3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-139450-100mg-safety-datasheet.pdf