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Purine phosphoribosyltransferase-IN-1

Purine phosphoribosyltransferase-IN-1

Item no.	HY-144294-1ea
Manufacturer	MedChem Express
CASRN	2784631-28-1
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Tomáš Klejch, et al. Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J Med Chem. 2022 Mar 10;65(5):4030-4057.
Smiles	O=P(O[Na])(O[Na])COC[C@@H](OC[C@@H](P(O[Na])(O[Na])=O)O)CN1C=NC2=C1N=C(N)NC2=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Parasite
Shipping Temperature	Room temperature
Molecular Weight	531.17
Product Description	Purine phosphoribosyltransferase-IN-1 (Compound (S, R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with Ki values of 50, 20, and 2 nM, respectively[1].
Manufacturer - Research Area	Infection
Solubility	10 mM in DMSO
Manufacturer - Pathway	Anti-infection
Isoform	Plasmodium
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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