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sEH/AChE-IN-4

sEH/AChE-IN-4

Item no.	HY-145833A-1ea
Manufacturer	MedChem Express
CASRN	2490589-12-1
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.
Smiles	O=C(N1CCC(CC1)NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CCCCNC3=C4C(C[C@H]5C[C@@H]4CC(C)=C5)=NC6=CC(Cl)=CC=C63
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Cholinesterase (ChE); Epoxide Hydrolase
Shipping Temperature	Room temperature
Molecular Weight	670.16
Product Description	sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].
Manufacturer - Research Area	Cancer; Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	AChE; BChE
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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