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Tau-aggregation-IN-1

Tau-aggregation-IN-1

Item no.	HY-146135-1ea
Manufacturer	MedChem Express
CASRN	1619269-19-0
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C28H37N5O2S
Citations	[1]Iva Ziu, et al. The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorg Med Chem. 2020 Sep 15;28(18):115667.
Smiles	OC(C=C1C(C=C2)=CC=C2N(CC3)CCN3CCN([C@H]4CC5=C(N=C(S5)N)CC4)CCC)=C(C=C1)O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Dopamine Receptor; Microtubule/Tubulin
Shipping Temperature	Room Temperature
Molecular Weight	507.69
Product Description	Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].
Manufacturer - Research Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Neuronal Signaling
Isoform	D2 Receptor; D3 Receptor
Clinical information	No Development Reported

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