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SK-575-NEG

SK-575-NEG

Item no.	HY-147101-1ea
Manufacturer	MedChem Express
CASRN	2523017-04-9
Amount	1 ea
Quantity options	100 mg 1 ea 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Cao C, et al. Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. J Med Chem. 2020 Oct 8;63(19):11012-11033.
Smiles	O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCCCCCCC(NCCNC4=CC=CC(C(N5C6C(N(C)C(CC6)=O)=O)=O)=C4C5=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	PARP
Shipping Temperature	Room Temperature
Product Description	SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2, 6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics
Isoform	PARP1
Clinical information	No Development Reported

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