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FXIa-IN-9

FXIa-IN-9

Item no.	HY-150682-1ea
Manufacturer	MedChem Express
CASRN	2816108-87-7
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Guozhang Xu, et al. Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. J Med Chem. 2022 Jul 21.
Smiles	CN1N=NC=C1C2=CN(N=C2)C(CCOC(F)F)C3=CC=C(C=[N+]3[O-])C4=C(C=CC(Cl)=C4F)N5N=NC(Cl)=C5
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Factor Xa
Shipping Temperature	Room temperature
Molecular Weight	580.35
Product Description	FXIa-IN-9 (compound 3f) is a potent and selective FXIa inhibitor. FXIa-IN-9 can bind with FXIa and form hydrogen bond (human FXIa Ki: 0.17 nM, rabbit FXIa Ki: 0.5 nM). FXIa-IN-9 also has anticoagulant activity, and can be used in the research of thromboembolic diseases such as atrial fibrillation, stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism[1].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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