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(R)-(-)-Gossypol

(R)-(-)-Gossypol

Item no.	HY-15464-1ea
Manufacturer	MedChem Express
CASRN	90141-22-3
Amount	1 ea
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.82
Formula	C30H30O8
Citations	Cancer Lett. 2019 Oct 1;461:31-43. Clin Transl Med. 2021 Jun;11(6):e467. Patent. US20220162561A1. Microb Pathog. 2024 Sep 21:106960. Transbound Emerg Dis. 2023 Nov 11. Nat Commun. 2023 Jun 10;14(1):3445. Patent. US20220162561A1. [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. [2]Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.
Smiles	OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	AT-101; R-(-)-gossypol acetic acid
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; Bcl-2 Family
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	518.55
Product Description	(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 200 mg/mL
Manufacturer - Pathway	Apoptosis; Autophagy
Isoform	Bcl-2; Bcl-xL; Mcl-1
Clinical information	Phase 3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15464-1ea-safety-datasheet.pdf