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Simvastatin-d11

Simvastatin-d11

Item no.	HY-17502S-5mg
Manufacturer	MedChem Express
CASRN	1002347-74-1
Amount	5 mg
Quantity options	1 ea 1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.\|[2]Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.\|[3]others
Smiles	[2H]C([2H])([2H])C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H]3C[C@H](CC(O3)=O)O)C)=C[C@@H](C1)C)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	MK 733-d11
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR); Isotope-Labeled Compounds; Mitophagy
Shipping Temperature	Room temperature
Molecular Weight	429.63
Product Description	Simvastatin-d11 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].
Manufacturer - Research Area	Cancer; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others
Clinical information	No Development Reported

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