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Carvedilol-d5

Carvedilol-d5

Item no.	HY-B0006S2-1mg
Manufacturer	MedChem Express
CASRN	929106-58-1
Amount	1 mg
Quantity options	1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.\|[2]Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22.\|[3]Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.\|[4]Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.
Smiles	COC(C=CC=C1)=C1OCCNC([2H])([2H])C(O)([2H])C([2H])([2H])OC2=C3C4=CC=CC=C4NC3=CC=C2
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	BM 14190-d5
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Adrenergic Receptor; Autophagy; Isotope-Labeled Compounds
Shipping Temperature	Room temperature
Molecular Weight	411.51
Product Description	Carvedilol-d5 is deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Neuronal Signaling; Others
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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