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Lurasidone

Lurasidone

Item no.	HY-B0032A-500mg
Manufacturer	MedChem Express
CASRN	367514-87-2
Amount	500 mg
Quantity options	100 mg 10 mg 1 mg 200 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.49
Citations	[1]Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81.\|[2]Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937. Antibiotics (Basel). 2024 Mar 28, 13(4), 308.\|bioRxiv. 2024 Jan 14.\|J Med Chem. 2024 Apr 25;67(8):6144-6188.\|J Ocul Pharmacol Ther. 2024 Aug 29.\|Marmara Pharm J. 2017;21 (4): 931-937.\|Marmara Pharm J. 2017;21 (4): 931-937.\|Nature. 2023 Dec;624(7992):672-681.\|ACS Chem Neurosci. 2020 Jan 15;11(2):173-183.\|Marmara Pharm J. 2017;21 (4): 931-937.
Smiles	O=C([C@H]1[C@H]2C[C@H](CC2)[C@@H]31)N(C[C@H](CCCC4)[C@@H]4CN5CCN(CC5)C6=NSC7=CC=CC=C67)C3=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	SM-13496
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor; Dopamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	492.68
Product Description	Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 20.83 mg/mL (ultrasonic)\|Ethanol: 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	5-HT1 Receptor; 5-HT7 Receptor; D2 Receptor; mLAG-3; MUC3
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B0032A-500mg-safety-datasheet.pdf