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Amiloride

Amiloride

Item no.	HY-B0285-1ea
Manufacturer	MedChem Express
CASRN	2609-46-3
Amount	1 ea
Quantity options	100 mg 10 mM/1 mL 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.96
Citations	[1]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.\|[2]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.\|[3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91. ACS Nano. 2023 May 9;17(9):8141-8152. Acta Biomater. 2025 Jul 1:201:171-186. Adv Funct Mater. 2024 Oct 31. Adv Funct Mater. 2025 Aug 3. Adv Sci (Weinh). 2024 Mar;11(9):e2307880. Adv Sci (Weinh). 2025 May 14:e2406150. Am J Transl Res. 2021 Jul 15;13(7):7538-7555. Anal Chem. 2025 Jun 17;97(23):12026-12034. Biomaterials. 2026 Jan:324:123541. Cell Commun Signal. 2023 May 4;21(1):99. Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. Cell Mol Biol Lett. 2024 Dec 3;29(1):149. Cell Physiol Biochem. 2018;51(6):2564-2574. Cell Rep Med. 2025 Jul 15;6(7):102208. Commun Biol. 2022 Nov 14;5(1):1248. Environ Sci Technol. 2021 Mar 2;55(5):3144-3155. FASEB J. 2025 Jan 15;39(1):e70298. Int J Biol Macromol. 2024 Aug 5;277(Pt 3):134517. J Am Chem Soc. 2018 Dec 12;140(49):17234-17240. J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. J Control Release. 2025 Nov 20:389:114450. J Hazard Mater. 2025 Dec 5:500:140498. J Leukoc Biol. 2024 Jul 16:qiae159. J Nanobiotechnology. 2020 Jan 31;18(1):26. J Pharm Anal. 2025 Jul;15(7):101182. J Pharm Biomed Anal. 2021 Feb 20:195:113870. Mater Today Bio. 2025 Mar 27:32:101712. Microb Pathog. 2019 Jul 18:103638. Mol Neurodegener. 2025 Jul 23;20(1):84. Mol Pharm. 2025 Apr 7;22(4):2182-2192. Nanotechnology. 2018 Feb 23;29(8):085101. Nat Biomed Eng. 2024 Nov;8(11):1469-1482. Nat Nanotechnol. 2024 Dec;19(12):1903-1913. Small Methods. 2021 Apr;5(4):e2001047. Theranostics. 2019 May 31;9(13):3732-3753. University of Toronto. 2025. Acta Pharm Sin B. 2024 Dec;14(12):5418-5434. Adv Sci (Weinh). 2025 Apr 3:e2412356. Biomaterials. 2022 May;284:121529. Biosens Bioelectron. 2025 Jan 25:274:117184. Br J Pharmacol. 2020 Aug;177(15):3473-3488. Cell Mol Immunol. 2024 Aug;21(8):826-841. Cell Rep. 2022 May 31;39(9):110880. Food Chem. 2024 Sep 8;463(Pt 1):141196. Int J Biol Macromol. 2022 May 15:207:559-569. iScience. 2022 Oct 19;25(12):105403. J Cell Biol. 2025 May 5;224(5):e202405060. J Ethnopharmacol. 2022 Jun 28:292:115171. J Neuroinflammation. 2022 Feb 22;19(1):53. J Zhejiang Univ Sci B. 2025 May 28;26(5):461-476. mBio. 2025 Mar 12;16(3):e0378724. Res Sq. 2025 Nov 16. Sci Total Environ. 2021 Jul 20:779:146523. SSRN. 2025 Aug 21. Theranostics. 2020 May 17;10(15):6581-6598. Transl Res. 2024 Jan:263:53-72.
Smiles	O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	MK-870
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Apoptosis; Sodium Channel; TRP Channel
Manufacturer - HS Code	H301, H311, H331
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	229631
Product Description	Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Manufacturer - Research Area	Metabolic Disease; Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched
UNSPSC Code	12352005
Precautionary	H301, H311, H331

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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