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Paroxetine-d4 (hydrochloride)

Paroxetine-d4 (hydrochloride)

Item no.	HY-B0492S1-5mg
Manufacturer	MedChem Express
CASRN	2714485-95-5
Amount	5 mg
Quantity options	1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.16
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.\|[2]Lassen TR, et al. Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction. Basic Res Cardiol. 2017 May;112(3):26.\|[3]Liu RP, et al. Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. J Neuroinflammation. 2014 Mar 12;11:47.\|[4]Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.\|[5]Wang Q, et al. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep. 2017 Mar 28;7:45364.\|[6]Zarei M, et al. Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J. 2014;18(2):94-100.
Smiles	FC(C([2H])=C1[2H])=C([2H])C([2H])=C1[C@H](CCNC2)[C@@H]2COC3=CC=C(OCO4)C4=C3.Cl
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	BRL29060-d4 (hydrochloride),BRL29060A-d4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; G Protein-coupled Receptor Kinase (GRK); Isotope-Labeled Compounds; Serotonin Transporter
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	369.85
Product Description	Paroxetine-d4 (hydrochloride) is deuterium labeled Paroxetine (hydrochloride). Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14?μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	10 mM in DMSO\|DMSO: 100mg/mL (ultrasonic)\|H2O: 5mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Neuronal Signaling; Others
Isoform	GRK2
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-B0492S1-5mg-safety-datasheet.pdf