Comparison

L-Asparagine-4-13C (monohydrate) European Partner

Item no. HY-N0667S4-5mg
Manufacturer MedChem Express
CASRN 286437-12-5
Amount 5 mg
Quantity options 10 mg 1 ea 1 mg 5 mg
Category
Type Chemicals
Specific against other
Citations [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-236.|[2]Batool T, et al. A Comprehensive Review on L-Asparaginase and Its Applications. Appl Biochem Biotechnol. 2016 Mar;178(5):900-23.|[3]Asselin BL, et al. In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase. Cancer Res. 1989 Aug 1;49(15):4363-8.|[4]Horvath TD, et al. Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer. Metabolites. 2019 Jan 9;9(1):10.|[5]Kravtzoff R, et al. Erythrocytes as carriers for L-asparaginase. Methodological and mouse in-vivo studies. J Pharm Pharmacol. 1990 Jul;42(7):473-6.|[6]Ilaria M Michelozzi, et al. Acute myeloid leukaemia niche regulates response to L-asparaginase. Br J Haematol. 2019 Aug;186(3):420-430. doi: 10.1111/bjh.15920.
Smiles N[13C](C[C@H](N)C(O)=O)=O.[H]O[H]
ECLASS 10.1 32160000
ECLASS 11.0 32160000
UNSPSC 12000000
Alias (-)-Asparagine-4-13C (monohydrate),Asn-4-13C (monohydrate),Asparamide-4-13C (monohydrate)
Shipping Condition Room temperature
Available
Manufacturer - Type
Isotope-Labeled Compounds
Manufacturer - Targets
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
Shipping Temperature
Room temperature
Molecular Weight
151.13
Product Description
L-Asparagine-4-13C monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
Manufacturer - Research Area
Inflammation/Immunology
Solubility
10 mM in DMSO
Manufacturer - Pathway
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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