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Oligomycin

Oligomycin

Item no.	HY-N6782-25mg
Manufacturer	MedChem Express
CASRN	1404-19-9
Amount	25 mg
Quantity options	10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.0
Citations	[5]Shchepina LA, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149-8157.\|[1]Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796.\|[2]SMITH RM, et al. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970.\|[3]López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.\|[4]Gong Y, et al. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288(5):C1023-C1029.
Smiles	O=C1/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@](O)(C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@H](CC)CC[C@]2([H])O[C@@]3(O[C@@H](C[C@H](O)C)[C@@H](C)CC3)[C@H]([C@@](O1)([H])[C@@H]2C)C)=O)=O.O=C4/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@H](C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@@](CC)([H])CC[C@]5([H])O[C@@]6(O[C@](C[C@H](O)C)([H])[C@@H](C)CC6)[C@H]([C@@](O4)([H])[C@@H]5C)C)=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; ATP Synthase; Fungal; Oxidative Phosphorylation
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Product Description	Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells[1][2][3][4].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: 20 mg/mL (ultrasonic; warming)\|Ethanol: 30 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-N6782-25mg-safety-datasheet.pdf