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Diethyl maleate

Diethyl maleate

Item no.	HY-Y1147-500mg
Manufacturer	MedChem Express
CASRN	141-05-9
Amount	500 mg
Quantity options	100 mg 500 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.57
Citations	[1]Andrea Gille, et al. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019 Jan;20:19-27.\|[2]Weber CA, et al. Depletion of tissue glutathione with diethyl maleate enhances hyperbaric oxygen toxicity. Am J Physiol. 1990 Jun;258(6 Pt 1):L308-12.\|[3]Deneke SM, et al. Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia. Am J Physiol. 1989 Oct;257(4 Pt 1):L265-71.
Smiles	O=C(OCC)/C=C\C(OCC)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Maleic acid diethyl ester
Shipping Condition	Room temperature
Available
Manufacturer - Type	Biochemical Assay Reagents
Manufacturer - Targets	Biochemical Assay Reagents
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	172.18
Product Description	Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO-. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO: 100 mg/mL (ultrasonic)\|Ethanol: ≥ 100 mg/mL
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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HY-Y1147-500mg-safety-datasheet.pdf