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Cl-amidine hydrochloride

Cl-amidine hydrochloride

Item no.	TMO-T10831L-100mg
Manufacturer	TargetMol
CASRN	1373232-26-8
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C14H20Cl2N4O2
Smiles	Cl.NC(=O)[C@H](CCCNC(=N)CCl)NC(=O)c1ccccc1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	PAD,Apoptosis
Shipping Condition	Cool pack
Available
Manufacturer - Targets	PAD\|\|\|MicroRNA\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	347.24
Description	Cl-amidine hydrochloride is an orally available PAD inhibitor that blocks histone 3 deimination and neutrophil extracellular trap formation and improves survival in septic mice. It induces apoptosis in cancer cells and induces miR-16 to cause cell cycle arrest.
Pathways	Apoptosis\|\|\|Chromatin/Epigenetic
Bioactivity	Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 Î¼M for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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