JI051

Item no.	TMO-T11718-500mg
Manufacturer	TargetMol
CASRN	2234281-75-3
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C22H24N2O3
Smiles	CCOc1ccccc1CCNC(=O)\C=C\c1c[nH]c2c(OC)cccc12
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	JI-051
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Gamma-secretase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	364.44
Description	JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells.
Pathways	Stem Cells\|\|\|Neuroscience\|\|\|Proteases/Proteasome
Bioactivity	JI051, Anti-cancer activity. is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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