SAR405

Item no.	TMO-T12831L-200mg
Manufacturer	TargetMol
CASRN	1523406-39-4
Amount	200 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C19H21ClF3N5O2
Smiles	C[C@@H]1COCCN1c1cc(=O)n2CC[C@H](N(Cc3cncc(Cl)c3)c2n1)C(F)(F)F
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	PI3K\|\|\|Autophagy
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	443.85
Description	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
Pathways	Autophagy\|\|\|PI3K/Akt/mTOR signaling
Bioactivity	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitorÂ (IC50:1.2 nM; Â Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells.Â SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic tar

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