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(S,R,S)-AHPC-Me hydrochloride

(S,R,S)-AHPC-Me hydrochloride

Item no.	TMO-T13671-200mg
Manufacturer	TargetMol
CASRN	1948273-03-7
Amount	200 mg
Quantity options	100 mg 10 mg 1 g 200 mg 25 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C23H33ClN4O3S
Smiles	Cl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	VHL ligand 2 hydrochloride,E3 ligase Ligand 1
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Ligand for E3 Ligase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	481.05
Description	(S, R, S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is utilized in the synthesis of ARV-771, a potent BET protein degrader. It selectively degrades BET protein in castration-resistant cells with a DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, it serves as the VHL ligand from (S, R, S)-AHPC for recruiting von Hippel-Lindau (VHL) protein.
Pathways	PROTAC
Bioactivity	(S, R, S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. (S, R, S)-AHPC-Me h

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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