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Ranirestat

Ranirestat

Item no.	TMO-T16723-500mg
Manufacturer	TargetMol
CASRN	147254-64-6
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C17H11BrFN3O4
Smiles	Fc1cc(Br)ccc1CN1C(=O)c2cccn2[C@@]2(CC(=O)NC2=O)C1=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	AS3201,SX3030,SX-3030,AS 3201,AS-3201
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Reductase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	420.19
Description	Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
Pathways	Metabolism\|\|\|Endocrinology/Hormones
Bioactivity	Ranirestat effective and orally active aldose reductase inhibitor ( IC50s: 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively and a Ki: 0.38 nM for recombinant human AR). Ranirestat has a neuroprotective effect on diabetic retinas.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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