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AVN-101

AVN-101

Item no.	TMO-T26690-200mg
Manufacturer	TargetMol
CASRN	1061354-48-0
Amount	200 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 200 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C21H25ClN2
Smiles	Cl.CN1CCC2=C(C1)C1=CC(C)=CC=C1N2CCC1=CC=CC=C1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Histamine Receptor,5-HT Receptor,5-HT Receptor,Adrenergic Receptor,Adrenergic Receptor,Histamine Receptor,Histamine Receptor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	5-HT Receptor\|\|\|Histamine Receptor\|\|\|Adrenergic Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	340.89
Description	AVN-101 is a highly potent 5-HT7 receptor antagonist with a Ki value of 153 pM. AVN-101 also exhibits considerable affinity for histamine H1 (Ki value of 0.58 nM) and adrenergic α2A, α2B and α2C (Ki values of 0.41-3.6 nM) receptors. AVN-101 has shown good oral bioavailability and brain-blood barrier permeability, low toxicity and reasonable efficacy in animal models of central nervous system diseases.
Pathways	GPCR/G Protein\|\|\|Neuroscience\|\|\|Immunology/Inflammation
Bioactivity	AVN-101 is a potent 5-HT7 receptor antagonist.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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