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LSN2814617

LSN2814617

Item no.	TMO-T27855-500mg
Manufacturer	TargetMol
CASRN	1313498-17-7
Amount	500 mg
Quantity options	100 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C18H20FN5O
Smiles	C(C)(C)(C)C=1N2C(C[C@H](CC2)C3=NC(=NO3)C4=CC=C(F)C=C4)=NN1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	LSN-2814617,LSN 2814617
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	341.38
Description	LSN2814617 is an orally active, potent, brain-penetrant, and selective mGlu 5 (metabotropic glutamate 5) positive allosteric modulator (PAM), with EC 50 values of 52 nM (Human mGlu5) and 42 nM (rat mGlu5). In vivo EEG studies demonstrated that LSN2463359 has marked wake-promoting properties with minimal rebound hypersomnolence, and it can be used for schizophrenia research [1].
Pathways	Others
Bioactivity	LSN2814617 is a potent, selective positive allosteric modulator at the mGlu5 receptor with EC50 value of 24 nM. LSN2814617 reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-in

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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