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Niraparib hydrochloride

Niraparib hydrochloride

Item no.	TMO-T3353-50mg
Manufacturer	TargetMol
CASRN	1038915-64-8
Amount	50 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C19H20N4O
Smiles	C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1.Cl
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	MK-4827 hydrochloride,MK-4827 (hydrochloride)
Shipping Condition	Cool pack
Available
Manufacturer - Targets	PARP\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	356.85
Description	Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. By inhibiting PARP activity, niraparib hydrochloride increases DNA strand breaks, leading to genomic instability and apoptosis. The PARP family of proteins detects and repairs single-strand DNA breaks via the base-excision repair (BER) pathway.
Pathways	Chromatin/Epigenetic\|\|\|Apoptosis\|\|\|DNA Damage/DNA Repair

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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