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MC-Val-Cit-PABC-PNP

MC-Val-Cit-PABC-PNP

Item no.	TMO-T3503-1g
Manufacturer	TargetMol
CASRN	159857-81-5
Amount	1 g
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 g 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C35H43N7O11
Smiles	[C@H](C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1)=O)(NC([C@@H](NC(CCCCCN3C(=O)C=CC3=O)=O)C(C)C)=O)CCCNC(N)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
Shipping Condition	Cool pack
Available
Manufacturer - Targets	ADC Linker\|\|\|AChR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	737.76
Description	MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug.
Pathways	Neuroscience\|\|\|Antibody-drug Conjugate/ADC Related
Bioactivity	MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of th

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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